Acetaminophen metabolism explained "simply" Since it's been blowing up my feed this week (this is not considering metabolic fates changes when pregnant) Your liver normally clears acetaminophen (Apap) safely, but in overdose, its 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Simplify Rx Hmm Concept cleared from Simplify Rx Instagram Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram