Sex differences in glutathione metabolism and acetaminophen toxicity Tylenol's Impact on Glutathione and Liver Damage Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link The History of Acetaminophen Office for Science and Society McGill University