Acetaminophen metabolism Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Pharmacokinetic profile of metabolites by heart cutting two dimensional liquid chromatography: A focus on paracetamol analysis ScienceDirect Unveiling the molecular basis of paracetamol induced hepatotoxicity: Interaction of N acetyl p benzoquinone imine with mitochondrial succinate dehydrogenase ScienceDirect Napqi hi res stock photography and images Alamy