Oral Melanotic Macule: Symptoms and Treatment Skinsight AD :: Annals of Dermatology An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Multifocal pigmentation of the oral mucosa The Journal of the American Dental Association Lip Pigmentation Treatment in Singapore