Glutathione vs Vitamin C: Which Is Better for Skin Glowing? How to Take Glutathione Effectively: Best Forms, Timing & Tips Can you take glutathione without vitamin C? The simple answer: NO! Glutathione will not work without Vitamin C. Glutathione remains in two states, active and inactive. When it's in its active state, Vitamin C vs Glutathione whats the difference? Both brighten the look of skin but they work in different ways. Vitamin C helps visibly brighten and improve the appearance of sun damage while Glutathione Injections For Skin Whitening: A Complete Guide