Pyridoxine induces glutathione synthesis via PKM2 mediated Nrf2 transactivation and confers neuroprotection Nature Communications Your liver is doing over 500 jobs every single day. Filtering toxins. Processing hormones. Managing inflammation. Supporting energy, skin, digestion, and metabolism. And one of the biggest things it relies on is The KEAP1 NRF2 System: a Thiol Based Sensor Effector Apparatus for Maintaining Redox Homeostasis Physiological Reviews American Physiological Society Sulforaphane boosts our natural cellular defenses. It does this by activating Nrf2, our body's primary detoxification, anti inflammatory, and antioxidant pathway. Nrf2 turns on phase 2 detoxification enzymes, helping us deal with daily Nrf2dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis Morales Pantoja 2016 Journal of Neurochemistry Wiley Online Library