The parent compounds of acetaminophen (US market in 1955 in the US as Tylenol and other products) were first discovered in 1886 (acetanilide) and 1887 (phenacetin). These were the earliest synthetic fever Sex differences in glutathione metabolism and acetaminophen toxicity Two chromatographic methods for analyzing paracetamol in spiked human plasma with its toxic metabolite, N acetyl parabenzoquinone imine and its antidote, N acetyl l cysteine Scientific Reports Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link