PGC 1 Induces Susceptibility To Acetaminophen Driven Acute Liver Failure Scientific Reports Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Hidden Impact of Acetaminophen Well Rooted Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen ScienceDirect Inflammasome activation as a key driver of acetaminophen induced hepatotoxicity: Mechanisms and emerging therapeutics EurekAlert!