Inflammasome activation as a key driver of acetaminophen induced hepatotoxicity: Mechanisms and emerging therapeutics EurekAlert! Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: The gamma glutamyl pathway after glutathione depletion due to Download Scientific Diagram g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine