Loss of glucose 6 phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells PNAS Visit our website G6PDHelp.com and Join our Facebook Support Group Message us for details! Glucose 6 phosphate dehydrogenase deficiency The Lancet Glucose 6 phosphate dehydrogenase (G6PD) deficiency X linked recessive Xq28 is not true recessive as heterozygotes can express the trait; G6PD > No NADPH > No RBC glutathione protection > free radical damage hemolysis Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black