Storage lesion: History and perspectives Alterations in red blood cells during condition of oxidative stress. Download Scientific Diagram In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Interplay between Erythrocyte Peroxidases and Membrane IntechOpen Hemolytic Anemias Part 4: G6PD Deficiency; Pathophysiology,Morphology, clinical features