Pigmented Lesions of the Oral Mucosa Pocket Dentistry Is focal melanotic lesion potentially malignant? A case report ScienceDirect This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips. Lingual melanotic macule the first case report in an adult patient* Anais Brasileiros de Dermatologia Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor