Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Good ol' paracetamol: 'But an overconsumption takes its toll' Journal of Anaesthesia Practice Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acute acetaminophen paracetamol toxicity Paracetamol metabolism. Download Scientific Diagram