Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Is Tylenol Bad? 5 Dangers for Children & Adults Done With Diligence Tylenol And Glutathione Invigor Medical Liver injury induced by paracetamol and challenges associated with intentional and unintentional use Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.